Nicole Lykens

Company: Novo Nordisk

Job title: Director of Neurobiology, Global Nucleic Acid Therapies (GNAT)

Seminars:

siRNA Brain Shuttle Strategies for Neurometabolic Modulation 2:30 pm

Overviewing neurometabolic axis and CS targets by targeting central regulators of hunger, satiety, and hedonic drive The impact of blood-brain barrier on distribution to different brain regions as compared to intrathecal injection as illustrated through ISH imaging analysisRead more

day: Day 2

Panel Discussion: Brain Shuttles Beyond TFR1: What Will Be the Next Hot Brain Shuttle? 3:00 pm

Evaluate the opportunities in overcoming target delivery challenges with TfR1 overexpression and off-target specificity Explore small molecules, APOE1 peptides, nanopeptides, carbohydrates, LNPs as alternative ligands comparing pros, cons and negatives; evaluating opportunities where different ligands might be more ‘fit-for-purpose’Read more

day: Day 2