About Event

Perfect Your Oligonucleotide Pipeline to Slow, Cure & Prevent Neurodegeneration

In a landscape where traditional treatments often fall short, oligonucleotide therapeutics have emerged as game-changers delivering precise targeting and potentially life-altering outcomes in neuroscience. As neurology overtakes cancer as the number one indication prioritized by oligonucleotide drug developers, now is the time to stay at the forefront of ASO and siRNA innovation.

The 5th Oligonucleotides for CNS Summit offers you the chance to be a part of critical conversations discussing the latest brain shuttle innovation with Regeneron and Eli Lilly, translational tools including BBBoids, cryptic exon inclusion sites, derisking nonclinical toxicology with Servier and Roche, PKPD modelling and dose selection, ProQR's RNA editing, Novo Nordisk's neurometabolic modulation, Alnylam Pharmaceuticals' biomimetic chemistry and more.

What’s New for 2025?

Data

Unpublished insights and never-seen-before data

Presentations

Two tracked workshop day designed for chemists and biologists

Speakers

10 new presenting companies including Denali Therapeutics, Alnylam Pharmaceuticals and Novo Nordisk

Regulators

Regulator presence from Ron Wange, a former FDA expert and author of the non-clinical guidance for oligonucleotides

Content

A greater spread of content across neurogenetic, neurodegeneration, neuromuscular, neurodevelopmental, rare, and ultrarare indications, including Angelman’s syndrome, epilepsies and more!

Breaking News: Neurology Overtakes Oncology as the Number One Indication Prioritized by Oligonucleotide Drug Developers

Breaking News

Get involved in this meeting to be part of critical discussions and hear the latest advancements in brain delivery, chemistry, nonclinical safety, transforming the very future of RNA therapeutics for the brain.

Join Neurobiologists & Oligonucleotide Chemists to:

Discover novel conjugates beyond antibodies and TfR1, and optimize oligonucleotide chemistry, to enhance potency, safety and stability

Advance more efficient delivery systems to ensure target-specific CNS tropism with minimum efficacious doses

Explore the latest in vitro and in vivo models to test new compounds and optimize CNS biomarkers to assess oligonucleotide efficacy

Review innovative strategies for assessing ASO and siRNA delivery and distribution in the CNS

Uncover the latest novel approaches, including RNA editing and splice modulation, and foster cross-modality learnings

Who Will You Meet?

The 5th Oligonucleotides for CNS meeting unites 100+ key pharma and biotech across discovery biology, oligonucleotide chemistry, DMPK, pharmacology, CMC and platform technology.

Connect with C-Level executives to senior scientists, to hear the latest unpublished data, participate in heated panel discussions, attend structured group discussions and deep dive into workshop topics, uniquely available to this meeting.

Peer Perspectives:

Servier

"I was able to interact with experts in the field who were encountering the same challenges in ASO drug development. The intimate setting enabled easy flow of communication and open discussion between participants" 

Director, Clinical Pharmacology, Servier, Past Attendee

Takeda

"It was great to meet other people in the field and get their perspectives on different modalities" 

Quantitative Systems Pharmacology Modeler Professional, Takeda, Past Attendee