Neelroop Parikshak

Neelroop Parikshak

Company: Alnylam Pharmaceutical

Job title: Director, Next Wave Research

Seminars:

Reduced ALN-APP for Alzheimer’s Disease & Cerebral Amyloid Angiopathy 8:30 am

Look at work upstream to reduce amyloid production Demonstrate target engagement with the first siRNA to be used in the brain Highlight preclinical findings from AD models and CAA, highlighting reduced cognitive decline in mice and reduced bleeding Delve into clinical data highlighting target engagement and plans for CAARead more

day: Day 1

Panel Discussion: Turning Setbacks into Success: Lessons Learned from Clinical Trial Failures to Strengthen CNS Oligonucleotide Development 9:00 am

Explore common causes of clinical trial failures in CNS oligonucleotide programs, from delivery barriers to patient heterogeneity Share strategies for improving target validation, biomarker selection, and preclinical models to better predict clinical outcomes Discuss best practices for early safety assessment, managing off-target effects, and optimizing dosing strategies Examine how aligning trial design and development plans…Read more

day: Day 1

A Hanson Wade Group Company

© Copyright 2025 Hanson Wade | Design and site by Event Engine | Hanson Wade Limited is registered in England & Wales, number 06752216.
Registered Office: Eastcastle House, 27/28 Eastcastle Street, London, W1W 8DH.