Long Li

Company: Ractigen Therapeutics

Job title: CEO

Seminars:

Panel Discussion: Why is it so much Harder to Deliver Oligonucleotides to the Brain Compared to Other Organs? 11:30 am

Exploring that the rate-limiting step for oligonucleotides targeted for CNS indications is release of oligonucleotides from lysosome and brain tissue Evaluating novel delivery technologies across LNPs, ultrasound, viral particles and routes of administration in delivering oligonucleotides to the brain without compromising on potency, distribution, affinity or efficacy Reviewing the next step to optimizing structural design…Read more

day: Conference Day One

SCAD Platform for the Delivery of Duplex RNA to the CNS 11:00 am

SCAD (smart chemistry-aided delivery) is a simple yet effective platform for delivering duplex RNA including siRNA and saRNA to the CNS via intrathecal administration SCAD delivered siRNA can achieve profound and durable target gene knockdown in rodents, nonhuman primates and human SCAD platform has demonstrated a very favorable safety profileRead more

day: Conference Day One