Generation of hiPSC-Derived Neurotoxic Aged Astrocytes & Their Application for Drug Target Identification Through siRNA Screening
Time: 10:40 am
day: Day 1
Details:
- Glial cells, including astrocytes and microglia, play a crucial role in CNS drug development
- Introduce the generation of neurotoxic aged astrocytes derived from human iPSCs and the results of drug screening conducted with these cells
- Demonstrate the potential application of neurotoxic aged astrocyte model for identifying novel therapeutic target identification through combination of gene expression network analysis and siRNA screening
- Show the potential use of a microglia/astrocyte/neuron tri-culture system for pharmacology and toxicity assays
