Roundtable Discussion: Demonstrating Reduced Chronic Oligonucleotide Toxicity Across Both Rodents & NHP Models
Time: 11:30 am
day: Day 2
Details:
- Accumulate chronic toxicity data in NHPs to understand common threads in toxicities and understand the pathology underlying chronic toxicity
- Build cutting edge rodent models that can recapitulate chronic oligonucleotide toxicity by reverse translating observations in NHPs, overcoming the disconnect in toxicity observations between NHPs and rodent systems with oligonucleotides
- Integrate models into clinical practice to more robustly determine candidate safety before reaching clinical trials
