Pannel Discussion: Beyond Transferrin Receptors Unlocking Safer & More Specific CNS Oligo Delivery for the Next Generation of BBB Shuttles
- Reassessing the limitations of TfR1-mediated delivery including broad peripheral expression, systemic sink effects, tolerability concerns, and limited cell-type specificity and evaluating whether alternative receptors such as CD98, IGF1R, peptide ligands and LNP-enabled formats can deliver improved CNS selectivity
- Examining emerging BBB access strategies, including receptor alternatives and physical modulation approaches such as antibody-mediated opening or focused ultrasound, while balancing enhanced penetration against the biological risks of barrier disruption