Panel Discussion: Turning Setbacks into Success: Lessons Learned from Clinical Trial Failures to Strengthen CNS Oligonucleotide Development
Time: 9:00 am
day: Day 1
Details:
- Explore common causes of clinical trial failures in CNS oligonucleotide programs, from delivery barriers to patient heterogeneity
- Share strategies for improving target validation, biomarker selection, and preclinical models to better predict clinical outcomes
- Discuss best practices for early safety assessment, managing off-target effects, and optimizing dosing strategies
- Examine how aligning trial design and development plans with regulatory expectations can de-risk clinical progression
- Highlight real-world examples of how insights from failed programs have shaped more resilient second-generation approaches
