Panel Discussion: Diversifying CNS Delivery of Oligos: Nanoparticles, AAV, Peptide Carriers, Physical & Non- Physical BBB Modulation
- Exploring LNP strategies for CNS delivery, discussing their capacity to encapsulate and protect oligonucleotides, enhance systemic stability, modulate biodistribution, and potentially enable controlled transport across or around the blood–brain barrier
- Advancing peptide-mediated delivery approaches that utilize small targeting or cell-penetrating peptides to facilitate BBB traversal and intracellular uptake, evaluating their modularity, scalability, and potential advantages over antibody-based shuttle platforms
- Evaluating physical BBB modulation techniques, including focused ultrasound and microbubble-assisted disruption, to transiently increase permeability and enable localized brain access, while critically assessing reversibility, safety margins, spatial precision, and translational feasibility