Leveraging Computational Modeling for Precision Intra CSF Delivery in the CNS with FalconTM
Time: 1:30 pm
day: Day 2
Details:
- Unpack FalconTM as a systematic approach for developing intra-CSF drugs including disease-specific understanding of CSF drug interactions, systematically optimizing drug dose, formulation and biodistribution to maximize translational success
- Utilize high resolution MRI for better resolution and generation of computer models for advanced capacity for testing over in vivo/in vitro analysis
- Simulate a multitude of delivery scenarios and extrapolating protocols across species, to mimic the patient condition at different disease states and reduce the reliance on extensive animal studies
- Explore regulatory acceptance of computational modeling to support proof of concept in IND
- Advance indications across SMA, ALS/FTD and other neurodegeneration and more
