Targeting Sortilin: Enhancing CNS siRNA Delivery with Novel Peptide Conjugates
Time: 11:30 am
day: Day 1
Details:
- Structure-guided development of linear and cyclic peptides to optimize SORT1 binding
- Incorporation of non-canonical amino acids to improve metabolic stability and facilitate efficient siRNA payload delivery
- Rodent validation studies, focusing on brain distribution, transcript knockdown, and the transition toward non-human primate (NHP) models
