9:00 am Workshop B: Optimizing the Oligonucleotide Structure: Unravelling the Role of Linkage & Sugar Modifications in CNS Therapeutics
Time: 9:00 am
day: Pre-Conference Workshop Day - Track B P1
Details:
Given the pivotal role of linkages and sugars in the development of oligonucleotide developments for CNS, this workshop will explore the latest advancements, challenges and strategies to enhance the safety and efficacy of CNS-targeted siRNAs, ASOs and RNA aptamers.
Join this session to:
- Alter accessibility of 3’ and 5’ ends to create transient shapes improving delivery, specificity and potency of ASOs
- Adjust prime positioning in sugar’s phosphate back bone modifications, to protect from endonuclease degradation
- Understand the optimal applications for siRNA and ASO technology
- Perfect polarity and charge for optimized binding and bloodbrain barrier crossing
- Explore emerging trends in linkage and sugar ring modifications and future directions
- Evaluate the impact of sugar ring modifications on hybridization kinetics and binding affinity, for the oligonucleotide as crucial modifiers of target engagement in CNS tissue
