1:00 pm Workshop D: Refining the Next Antibody- Oligonucleotide Conjugates (AOC) & Delivery Chemistries
Time: 1:00 pm
day: Pre-Conference Workshop Day - Track B P2
Details:
Antibody-oligonucleotide conjugates (AOCs) represent a cutting-edge approach to improving targeted RNA therapeutics, offering enhanced precision in delivery, while overcoming key barriers such as biodistribution and cellular uptake. This workshop will focus on the latest advancements in AOC design, with a particular emphasis on brain shuttle strategies and delivery chemistry to optimize therapeutic outcomes for neurological diseases.
Join this session to:
- Leverage Transferrin Receptor mediated transport to enhance CNS penetration
- Ensure consistent Drug-Antibody Ratio (DAR) strategies to improve therapeutic efficacy
- Optimize scalable conjugation chemistry, following advances in linker chemistry, conjugate stability, and manufacturing scalability
- Translate insights from antibody-drug conjugates (ADCs) and other targeted delivery platforms to enhance AOC development
- Match disease areas with the most effective targeting strategies to ensure efficient drug uptake by diseased cells
- Enhance payload delivery and endosomal escape strategies to improve intracellular trafficking and prevent degradation before reaching the intended RNA target
