Roundtable Discussion: Conjugation vs Intrinsic Chemistry – Is Targeted CNS Delivery Worth the Structural Complexity?

• Evaluating whether receptor-mediated conjugation strategies provide a translational advantage over intrinsic chemistry optimization, given the absence of a validated receptor–ligand specific to CNS
• Examining the structural and operational complexity introduced by antibody–oligonucleotide constructs and the requirement for highly efficient delivery at low systemic doses to avoid toxicity risk
• Debating whether emerging alternatives or intrinsic chemistry tuning remains the more scalable and practical strategy for CNS programs

Speakers:

Jimmy Weterings

Vice President & Head of Oligonucleotide Therapeutics

Bonito Biosciences Inc.