Ken Yamada

Ken Yamada

Company: University of Massachusetts Medical School

Job title: Assistant Professor


Revealing Structurally Constrained Internucleotide (E)-Vinyl Phosphonate Backbone Impacts siRNA Potency & Allele Specificity 12:00 pm

Adding structure-constraining of sugars, such as 2′-fluoro and LNA, has been shown to enhance oligonucleotide stability and affinity to target mRNA Exploring the synthesis and impact of a structurally-constrained inter-nucleotide (E)-vinylphosphonate backbone (iE-VP) where we show iE-VP can modulate metabolic stability, enzyme interactions and siRNA activity Demonstrating how iE-VP induces significant mismatch-discriminating properties without compromising…Read more

day: Pre-Conference Discussion Day

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