Perfecting the Formula for Oligonucleotide Drugs: Rational Use of Chemical Modifications
Time: 2:00 pm
day: Day One PM
Details:
• Evaluating strategies in chemical modification to improve stability and potency of oligonucleotides in CNS the aim to deliver infrequent dosing and avoid repeated intrathecal administration
• Reviewing considerations in antisense chemistry to guide best decision making for each therapeutic
